Diamondbacks vs. White Sox odds, line, prediction, start time: 2025 MLB picks, June 25 bets from proven model

The Arizona Diamondbacks (41-38) and the Chicago White Sox (25-55) wrap up their three-game series with a contest on Wednesday afternoon. Arizona aims to complete the sweep over the White Sox after picking up wins on Monday and Tuesday. The Diamondbacks topped the White Sox 4-1 last night. Zac Gallen (5-8, 5.60 ERA) is on the mound for the Diamondbacks. Sean Burke (3-7, 4.50 ERA) gets the start for Chicago.   

First pitch from Rate Field is set for 2:10 p.m. ET. Arizona is a -141 favorite on the money line (risk $141 to win $100) in the latest Diamondbacks vs. White Sox odds from FanDuel Sportsbook, while the over/under for total runs scored is 9. Before making any White Sox vs. Diamondbacks picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.

Now, the model has set its sights on Diamondbacks vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Diamondbacks vs. White Sox, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Diamondbacks can win

Second baseman Ketel Marte is hitting .320 with 15 home runs and 32 RBI in 2025. In Tuesday’s win over the White Sox, Marte was 2-of-4 with a soIo home run. He’s recorded two-plus hits in five of his last six outings. 

Arizona heads into this game 11-6 against the run line in non-league games and 40-31 against the run line with equal rest as their opponent. In addition, they are 29-24 against the run line as the favorite. See which team to back at SportsLine.

Why the White Sox can win

Third baseman Miguel Vargas currently leads the team in home runs (10), RBI (34), OBP (.314) and hits (67). He’s tallied a hit in two of his four games. On June 21 against the Blue Jays, Vargas went 1-of-3 with a solo homer. 

Second baseman Lenyn Sosa heads into this matchup with a .269 batting average, four home runs, and 17 RBI. He has two games with two-plus hits in two of his last six games. On June 22 versus the Blue Jays, he was 2-of-4 with two base hits. See which team to back at SportsLine. 

How to make Diamondbacks vs. White Sox picks

SportsLine’s model is leaning Over on the total, projecting 10 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Diamondbacks vs. White Sox, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.